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. 2013 Apr 24;2(2):e000093. doi: 10.1161/JAHA.113.000093

Figure 1.

Figure 1.

NTM reduces hyperlipidemia, hyperglycemia, and weight gain in ldlr−/− mice fed a Western diet. At indicated times, plasma concentrations of cholesterol, triglycerides, and glucose were determined in mice fed a Western diet and treated with cSN50.1 peptide or saline by osmotic pump (A, C, D) or twice daily intraperitoneal injection (B). Mice were fasted overnight before blood collection. Results obtained at different time points represented separate groups of animals. A through C, Saline (white bars), cSN50.1 (black bars). A, Plasma concentrations of cholesterol and triglycerides at 1 week (n=10/group), 4 weeks (n=20/group), and 8 weeks (n=5/group). B, FPLC profile of plasma lipoproteins from ldlr−/− mice at 8 weeks (n=5/group). C, Glucose concentrations in plasma at 1 week (n=5/group), 4 weeks (n=20/group), and 8 weeks (n=5/group). D, Body weight gain (%) and total food intake (g/mouse) after 4 weeks (saline, n=10; peptide, n=20) of a Western diet. Shown are mean+SEM (*P<0.05, **P<0.005 and ***P<0.0005 by Mann–Whitney test). NTM indicates nuclear transport modifier; ldlr−/−, low‐density lipoprotein receptor deficient; CHOL, cholesterol; TRIG, triglycerides; FPLC, fast protein liquid chromatography; LDL, low‐density lipoprotein; HDL, high‐density lipoprotein; VLDL, very low‐density lipoprotein.