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. 2013 Apr 24;2(2):e000128. doi: 10.1161/JAHA.113.000128

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© 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell.

This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 1. — Endothelial function of subcutaneous resistance arteries in chronic kidney disease patients. The vasodilatory response to acetylcholine (Ach) of resistance arteries isolated from chronic kidney disease patients is mostly nitric oxide synthase‐dependent. A, Vasodilatory concentration‐response curves to acetylcholine were obtained without (no inhibitor) and after preincubation (15 minutes) with the nitric oxide synthase inhibitor N^ω‐nitro‐l‐arginine methyl ester (l‐NAME, 10⁻⁴ mol/L) in 15 patients, the cyclooxygenase inhibitor meclofenamate (meclo, 10⁻⁶ mol/L) in 4 patients, or the endothelin‐1 receptor type A blocker ABT‐627 (ET_ARA, 10⁻⁷ mol/L in 6 patients. The percent reduction of the maximal relaxation response to Ach is shown in (B). *P<0.01 vs no inhibitor.