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. 2013 Apr 24;2(2):e000128. doi: 10.1161/JAHA.113.000128

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© 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell.

This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 2. — Vascular function of subcutaneous resistance arteries in response to recombinant human erythropoietin (EPO). A, Endothelial function of subcutaneous resistance arteries isolated from chronic kidney disease patients. Vasodilatory concentration‐response curves to acetylcholine were obtained after preincubation (15 minutes) without or with increasing concentration of EPO (1, 10, and 20 IU/mL). Curves were repeated 4 times on the same artery in 10 patients. Concentration‐response curves to acetylcholine without or with 20 IU/mL EPO were performed on the same artery from 7 additional patients. B, Vasoconstrictor response to norepinephrine was not affected by EPO. Vasoconstrictor concentration‐response curves to norepinephrine were obtained after preincubation (15 minutes) without or with 20 IU/mL EPO (n=10 patients, curves performed with and without EPO on the same artery). C, Vasorelaxation response to sodium nitroprusside was not affected by EPO. Vasodilatory concentration‐response curves to sodium nitroprusside were obtained after preincubation (15 minutes) without or with 20 IU/mL EPO (n=8 patients, curves performed on the same artery). Values are means±SEM, *P<0.05 and **P<0.001 vs No EPO.