Table 4.
Respective HRs, Change in C‐Statistic, NRI and IDI for Cardiovascular Disease Events When Each Plaque Metric is Added to a Baseline Model With Risk Factors Shown in Table 3
| Variable | HR | HR Lower 95% CI | HR Upper 95% CI | P‐Value | Change in C‐Statistic | Lower 95% CI | Upper 95% CI | P‐Value | NRI (%) | P‐Value | IDI | P‐Value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Plaque >0% | 1.45 | 1.20 | 1.76 | <0.001 | 0.0046 | −0.0003 | 0.0094 | 0.065 | 2.0 | 0.201 | 0.0022 | 0.01 |
| Plaque ≥25% | 1.65 | 1.34 | 2.03 | <0.001 | 0.0059 | 0.0009 | 0.0109 | 0.02 | 2.1 | 0.201 | 0.0056 | <0.001 |
| Maximum of the ICA IMT, mm | 1.21 | 1.13 | 1.30 | <0.001 | 0.0068 | 0.0016 | 0.0120 | 0.01 | 2.9 | 0.079 | 0.0062 | <0.001 |
| Plaque or maximum of the far wall IMT >1.5 mm | 1.49 | 1.22 | 1.82 | <0.001 | 0.0057 | 0.0005 | 0.0108 | 0.033 | 2.7 | 0.107 | 0.0023 | 0.01 |
| Maximum of the ICA IMT >1.5 mm | 1.48 | 1.21 | 1.80 | <0.001 | 0.0053 | 0.0002 | 0.0104 | 0.042 | 3.2 | 0.060 | 0.0022 | 0.02 |
| Mean of the maximum ICA IMT, mm | 1.33 | 1.18 | 1.49 | <0.001 | 0.0065 | 0.0018 | 0.0112 | 0.007 | 5.2 | 0.002 | 0.0049 | <0.001 |
HR indicates hazard ratio; NRI, net reclassification improvement; IDI, integrated discrimination improvement; ICA, internal carotid artery; IMT, intima‐media thickness.