Table 3.
Population Attributable Risk of Psoriasis on Major Adverse Cardiovascular Events
| Baseline Rate Per 100 000/Year | Rate Ratio, Psoriasis (95% CI) | Rate Per 100 000/Year, Psoriasis | Excess Rate Per 100 000/Year, Psoriasis | Number of Excess Cases/Year Attributable to Psoriasis | |
|---|---|---|---|---|---|
| Mild psoriasis | |||||
| CV death | 256 | 1.03 (0.86 to 1.25) | 263.7 (220 to 320) | 7.7 (−36 to 64) | 520 (−2419 to 4320) |
| MI | 261 | 1.29 (1.02 to 1.63) | 336.7 (266 to 425) | 75.7 (5 to 164) | 5109 (352 to 11 099) |
| Stroke | 307.5 | 1.12 (1.08 to 1.16) | 344.4 (332 to 356) | 36.9 (25 to 49) | 2491 (1661 to 3321) |
| Severe psoriasis | |||||
| CV death | 256 | 1.39 (1.11 to 1.74) | 355.8 (284 to 445) | 99.8 (28 to 189) | 749 (211 to 1421) |
| MI | 261 | 1.70 (1.32 to 2.18) | 443.7 (345 to 569) | 182.7 (84 to 308) | 1370 (626 to 2310) |
| Stroke | 307.5 | 1.56 (1.32 to 1.84) | 479.7 (406 to 566) | 172.2 (98 to 258) | 1292 (738 to 1937) |
Estimates are based on 2008 US census data and current national rates of cardiovascular death, myocardial infarction, and stroke. The 95% CI estimates for the rate ratio are based on meta‐analysis results. CV indicates cardiovascular; MI, myocardial infarction.