Table 1.
Epidemiological Studies Reporting on the Use of CIMT and Carotid Artery Plaque in the Prediction of CHD and CVD Risk
| ARIC4 | CAPS5 | Framingham Offspring11 | MESA7 | |
|---|---|---|---|---|
| Patients, n | 13 145 | 4904 | 2965 | 6562 |
| Mean follow‐up, y | 15.1 | 8.5 | 7.2 | 7.8 |
| Events | ||||
| MI, n | 867 | 73 | NR | NR |
| CHD deaths/deaths, n | 159 | 72 | NR | NR |
| Other CVD events, n | Silent MI: 98; revasc.: 688 | AP or MI: 271 | Stroke: 74; CHD: 152; PAD: 26; CHF: 45 | Stroke: 139; incident CVD: 515 |
| Ultrasound data | ||||
| IMT segments | All (mean) | ICA, CCA, bifurcation | Max. ICA, mean CCA | Mean ICA, max. ICA |
| Plaque presence | Yes | Yes | Yes | Yes |
| AUC with CIMT/plaque measurements | ||||
| AUC (TRF) | 0.742 | 0.719 | 0.748 | 0.743 |
| AUC (CIMT+TRF) | 0.750 | 0.724 | 0.751 | 0.750 |
| AUC | 0.755* | 0.722* | 0.758* | — |
| AUC (plaque+TRF) | 0.751 | NR | 0.762 | 0.750 |
| NRI with CIMT/plaque measurements added to TRF | ||||
| NRI, % | 9.9* | NR | 7.3* | 5.0* |
| NRI (CCA), % | 16.2 | –1.4 | 0 | NR |
| NRI (ICA), % | NR | 1.6 | 7.6 | 7.0*/6.8* |
CIMT indicates carotid intima–media thickness; CHD, coronary heart disease; CVD, cardiovascular disease; ARIC, Atherosclerosis Risk in Communities; CAPS, Carotid Atherosclerosis Progression Study; MESA, Multi‐Ethnic Study of Atherosclerosis; MI, myocardial infarction; NR, not reported; revasc., coronary revascularizations; AP, angina pectoris; PAD, peripheral arterial disease; CHF, congestive heart failure; ICA, internal carotid artery, CCA, common carotid artery; AUC, area under curve; TRF, traditional risk factors; NRI, net reclassification index.
CIMT+plaque+TRF.
ICA+TRF.
CIMT+plaque.
Plaque.
Mean of the maximum IMT measured in ICA (based on CHD events).
Maximum IMT measured in ICA (based on CHD events).