Table 2. Genetic diversity of Neisseria meningitidis cps genes*.
| Region, locus | Size, bp | No. alleles | No. polymorphisms (%) | p-distance | dN/dS ratio | G+C content |
|---|---|---|---|---|---|---|
| MLST | ||||||
| abcZ | 433 | 11 | 52 (11) | 0.046 | 0.04 | 51 |
| adk | 465 | 7 | 18 (4) | 0.015 | 0.02 | 52 |
| aroE | 490 | 11 | 131 (7) | 0.102 | 0.28 | 56 |
| fumC | 465 | 12 | 27 (6) | 0.02 | 0.02 | 57 |
| gdh | 501 | 8 | 18 (4) | 0.014 | 0.05 | 52 |
| pdhC | 480 | 13 | 61 (13) | 0.041 | 0.08 | 56 |
|
pgm
|
450 |
10 |
62 (14) |
0.055 |
0.11 |
54 |
| Region B | ||||||
| ctrE | 2,115 | 13 | 386 (18) | 0.061 | 0.2 | 51 |
|
ctrF
|
1,260 |
12 |
59 (5) |
0.012 |
0.14 |
49 |
| Region C | ||||||
| ctrA | 1,179 | 11 | 175 (15) | 0.032 | 0.18 | 47 |
| ctrB | 1,164 | 8 | 264 (23) | 0.051 | 0.10 | 46 |
| ctrC | 726 | 8 | 177 (24) | 0.06 | 0.12 | 43 |
|
ctrD
|
651 |
7 |
87 (13) |
0.057 |
0.1 |
46 |
| Region D | ||||||
| rfbA | 867 | 13 | 75 (9) | 0.034 | 0.26 | 53 |
| rfbB | 1,083 | 15 | 312 (28) | 0.067 | 0.12 | 53 |
| rfbC | 558 | 14 | 124 (220 | 0.09 | 0.22 | 55 |
|
galE
|
1,020 |
15 |
382 (37) |
0.119 |
0.12 |
50 |
| Region E | ||||||
| tex | 2,274 | 13 | 173 (8) | 0.019 | 0.09 | 59 |
| NMC0060 | 1,007 | 8 | 24 (2.4) | 0.003 | 0.91 | 40 |
| NMC0061 | 345 | 5 | 24 (7) | 0.013 | 0.19 | 36 |
*Genes in region A were too diverse among serogroups for direct comparison. Region D′ was omitted because galE2 is truncated and rfbA, rfbB, and rfbC were duplicates. MLST, multilocus sequence type.