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Functional role of endoglin in cardiac fibrosis.
Notes: In heart failure, increased ventricular pressure overload stimulates TGFβ1 expression. In mice with normal endoglin expression (Eng+/+), endoglin promotes TGFβ1-induced type I collagen synthesis and cardiac fibrosis. Reduced endoglin expression in Eng+/− mice attenuates TGFβ1-induced pSmad-2/3, type I collagen expression, and cardiac fibrosis.
Abbreviation: TGFβ1, transforming growth factor beta-1.
