Figure 1.
Markov state transition model with CD4 states and arrows indicating the allowed transitions between states for a cohort followed for 52 weeks from clinic entry and initiating ART at week âkâ. Mortality occurs from each state each cycle.
Before ART initiation, transitions can occur between adjacent CD4 count states. After ART initiation, mortality is estimated as a function of CD4 count state at ART initiation and weeks since ART initiation, and thus there are no transitions between CD4 count states and the boxes are blank because individual patients may have a wide range of CD4 counts.