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Western blot analysis of bovine spongiform encephalopathy proteinease-resistant prion protein (PrPres) (lumbar spinal cord segments) in preclinical and clinically ill macaques. An atypical PrPres pattern was detectable in macaques euthanized during incubation from 3 years p.i. (macaque S11) to 6.5 years p.i. (macaque C1). All samples were co-stained with an anti-actin-antiserum. p.i., postinoculation; PK, proteinase K; mAb, monoclonal antibody.
