Table. Genetic polymorphisms in drug-resistance genes from relapsing isolates of Plasmodium vivax *.
| Gene | Chromosome | Polymorphism | Amino acid | Reference | Brazil | EAC01 | EAC02 | EAC03 |
|---|---|---|---|---|---|---|---|---|
| pvcrt | 1 | T330262C | 5′ UTR | T | C | C | ND | C |
| PVX_087980 | T330482C | 5′ UTR | T | T | T | T | T | |
| G330484T | 5′ UTR | G | G | G | G | G | ||
| C330495A | 5′ UTR | C | C | C | C | C | ||
| T331151C | Intron | T | C | C | C | C | ||
| T332453C | Intron | T | C | C | ND | C | ||
| A332874C | Intron | A | C | C | ND | C | ||
| G333391A | Intron | G | G | A | A | A | ||
| A333518G | Intron | A | A | G | G | G | ||
|
|
|
T333544C |
Intron |
T |
T |
C |
C |
C |
| pvmrp | 2 | G153936A | F1629 | G | G | ND | A | A |
| PVX_097025 | C154067T | H1586Y | C | C | C | C | C | |
| G154391A | V1478I | G | A | ND | A | A | ||
| G154567C | G1419A | G | G | G | G | G | ||
| T154646G | Y1393D | T | G | ND | G | G | ||
| T154979A | L1282I | T | T | T | T | T | ||
|
|
|
T155127G |
I1232 |
T |
T |
ND |
G |
G |
| pvdhfr | 5 | C964763G | S58R | C | A | G | G | G |
| PVX_089950 | T964796C | Y69 | T | C | T | T | T | |
| G964939A | S117N | G | A | A | A | A | ||
| G964970A | P127 | G | G | A | A | A | ||
|
|
|
A965106C |
I173L |
A |
C |
A |
A |
A |
| pvmdr1 | 10 | C361917G | K1393N | C | C | C | C | G |
| PVX_080100 | T362031C | K1355 | T | T | T | T | T | |
| A362870G | F1076L | A | A | G | G | G | ||
| G363032A | L1022 | G | G | G | G | G | ||
| T363169A | Y976F | T | T | A | A | T | ||
| G363223A | T958M | G | A | A | A | A | ||
| T363374G | M908L | T | G | G | G | G | ||
| G363563A | L845F | G | G | G | G | G | ||
| C364004T | G698S | C | C | T | T | T | ||
| T364509C | T529 | T | C | C | C | C | ||
| A364557T | S513R | A | A | T | T | T | ||
|
|
|
C364598T |
D500N |
C |
T |
C |
C |
C |
| pvdhps | 14 | G1256840A | Intron | G | G | A | A | A |
| PVX_123230 | T1257042C | P654 | T | T | C | C | C | |
| G1257064A | A647V | G | G | A | A | A | ||
| G1257856C | A383G | G | C | C | C | C | ||
| G1257859C | S382C | G | C | G | G | G | ||
| C1258389T | M205I | C | T | T | T | T | ||
| T1258579C | E142G | T | T | C | C | C |
*UTR, untranslated region; ND, not determined