Table 1.
Gliclazide concentrations (μg/g) 240 seconds after gliclazide injection (20 mg/kg) in the brain parts and total brain.
| Groups | Group 1: healthy Gliclazide n = 6 |
Group 2: healthy Gliclazide + DA n = 6 |
Group 3: diabetic Gliclazide n = 6 |
Group 4: diabetic Gliclazide + DA n = 6 | |
|---|---|---|---|---|---|
| Gliclazide concentration (μg/g)—mean ± SD |
BS | 1.57 ± 0.77 | 15.49 ± 9.53* | 11.51 ± 5.48# | 33.72 ± 19.58××,× |
| C | 2.22 ± 1.13 | 23.69 ± 11.45* | 19.17 ± 8.18# | 76.92 ± 34.82××,## | |
| LCH | 1.41 ± 0.75 | 1.87 ± 0.94 | 0.70 ± 0.38 | 6.93 ± 4.09××,× | |
| RCH | 2.46 ± 1.56 | 6.33 ± 4.03* | 2.88 ± 1.30 | 10.02 ± 6.43××,× | |
| B | 1.71 ± 1.03 | 9.15 ± 5.53* | 7.27 ± 3.41# | 22.00 ± 14.15××,× | |
LCH: left cerebral hemisphere; RCH: right cerebral hemisphere; BS: brain stem; C: cerebellum, B: total brain.
*Group 2 versus Group 1, P ≤ 0.05; #Group 3 versus Group 1, P ≤ 0.05; ×Group 4 versus Group 3, P ≤ 0.05; ##Group 4 versus Group 2, P ≤ 0.05; ××Group 4 versus Group 1, P ≤ 0.05.