Table 1.

NMDAR subunit gene and protein expression in the brain of schizophrenia patients or in the brain of rats exposed to lead during development. DG= dentate gyrus; CA= cornus ammonis; Hipp= Hippocampus; s.v= splice variants; PN= postnatal day.

Schizophrenia			Developmental Pb2+ Exposure
NMDAR Subunit Effect	Brain Region	Reference	NMDAR Subunit Effect	Age	Brain Region	Reference
NR1	DG, Hipp	Gao et al., 2000	NR1	PN50	CA, DG	Nihei et al., 2000
NR2B	CA2-CA3, Hipp		NR2A	PN50	DG
			NR2B	PN50	CA3
NR2B	Thalamus	Clinton et al., 2006	NR1-4 s.v.	PN50	DG
NR1	superior temporal cortex – cognitive impairment with no cognitive impairment	Humphries et al., 1996	NR1	PN50	CA, DG	Guilarte & McGlothan, 2003
NR1			NR1-2 s.v.	PN50	CA, DG
			NR1-4 s.v.	PN50	CA, DG
			NR1-b s.v.	PN50	CA, DG
NR1	dentate gyrus	Law & Deakin, 2001	NR1	PN50	CA, DG	Guilarte et al., 2003
NR1	Superior frontal cortex	Sokolov, 1998	NR1	PN14	CA1	Guilarte & McGlothan, 1998
			NR2A	PN14 & 21	CA1, DG
			NR2B	PN14 & 21	--
NR2A	anterior cingulate cortex	Woo et al., 2004
NR1	superior temporal gyrus	Le Corre et al., 2000	NR2A (protein)	PN14, 21, 28	Hipp	Nihei & Guilarte, 1999
NR1	dorsolateral prefrontal cortex/occipital cortex	Drachera et al., 2001	NR1	PN15, 20	CA, DG	Zhang et al., 2002
			NR2A	PN15, 20	CA, DG
			NR2D	PN20	CA, DG
NR1-4 s.v.	Hipp	Vrajova et al., 2010 (PCR)	NR2B	PN20	CA, DG
NR1-2 s.v.
NR2D	prefrontal cortex	Akbarian et al., 1996	NR1-a s.v.	PN14	CA	Guilarte et al., 2000
			NR1-a s.v.	PN14, 21	DG
			NR1-b s.v.	PN21	CA
			NR1-2 s.v.	PN21	CA4, DG
			NR1-4 s.v.	PN14	CA3
			NR1-4 s.v.	PN21	CA3