. Author manuscript; available in PMC: 2013 Jun 1.

Published in final edited form as: Neurotoxicology. 2011 Dec 9;33(3):560–574. doi: 10.1016/j.neuro.2011.11.008

Table 2.

Quantitative receptor autoradiography or radioligand receptor binding studies of NMDAR levels in the brain of schizophrenia patients or in the brain of rats exposed to lead during development. DG= dentate gyrus; CA= cornus ammonis; Hipp= Hippocampus; PN= postnatal day; EC= entorhinal cortex. (*) lead exposure started post-weaning.

Schizophrenia			Developmental Pb²⁺ Exposure

Radioligand	Brain Region	Reference	Radioligand	Age	Brain Region	Reference
³H-ifenprodil (NR1/NR2B)	Superior temporal cortex	Grinwood et al., 1999	³H-MK801 No change if Pb started as adult	PN14	forebrain	Guilarte & Miceli, 1992
³H-MK801/³H-TCP	cerebral cortex	Komhuber et al., 1989	³H-MK801	PN70-120	cerebral cortex	Guilarte et al., 1993
³H-MK801/³H-TCP	orbital frontal cortex	Simpson et al., 1992	³H-MK801	PN56-112	occipital cortex entorhinal cortex temporal cortex	Ma et al., 1997
³H-TCP	CA3-Hipp	Dean et al., 1999
³H-MK801	Hipp	Beneyto et al., 2007	³H-Ifenprodil (NR1/NR2B)	PN50	cerebral cortex	Toscano et al., 2002
			³H-CGP39653	adults	frontal cortex	Cory-Slechta et al., 1997 ^a
			³H-TCP	PN25	CA3-Hipp	Brooks et al., 1993
			³H-MK801	PN56-112	DG CA1, CA2-Hipp	Ma et al., 1997
			³H-MK801	PN14	Hipp, EC	Jett & Guilarte, 1995
			³H-ifenprodil	PN50	Hipp	Toscano et al., 2002
			³H-MK801	adults	DG, CA1-Hipp	Cory-Slechta et al., 1997 ^a

Pb exposure started post-weaning (PN21)