Table l. Demographics and Transplant Related Variables in BKV Replication Positive or Negative Group.
Variable | BKV Positive N=37 (31%) |
BKV Negative N=83 (69%) |
P Value* |
---|---|---|---|
Age (mean ±SD) | 46.8 ± 12.8 | 47.4 ± 13.5 | 0.9 |
Gender (% females) | 16 (43%) | 42 (51%) | 0.4 |
Race (% African-Americans) | 12 (32%) | 21 (25%) | 0.4 |
Deceased Donor Grafts (N=46) | 17 (46%) | 29 (35%) | 0.3 |
Number of HLA Mismatches (median) | 3 | 3 | 0.9 |
DGF (N=11) | 4 (11%) | 7 (8%) | 0.7 |
Ureteral Stent (N=52) | 17 (46%) | 35 (42%) | 0.7 |
Acute Rejection Treatment | |||
Within the First 6 months Post-Transplantation (N=16) | 4 (11%) | 12 (14%) | 0.6 |
Urine specimens were collected from 120 renal-allograft recipients at 6 months post-transplantation and urinary cell levels of BKV VP1 mRNA were quantified using BKV specific primers and TaqMan® probe in the real-time quantitative PCR assay (14). A subject was classified as BKV replication positive if the urinary cell BKV VP1 copy number was greater than >1 BKV VP1 mRNA copy / one pg total RNA.
P Values for categorical variables were derived using the chi-square test and for continuous variables using the Mann-Whitney test.