Fig 4.

Antigen-specific immune responses measured in PBMCs and monocytes isolated from lung tissue at necropsy. Box plots display vaccination group medians and interquartile ranges of antigen-specific IFN-γ-secreting cells measured by ELISpot assay in mononuclear cells isolated from peripheral blood (A and C) and lung tissue samples collected at necropsy (B and D). Panels A and B show the profiles of PPD-specific IFN-γ-secreting cells, and panels C and D show the profiles of Ag85A-specific IFN-γ-secreting cells.