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Survival times of hamsters immunized with Lig DNA vaccines or with killed whole leptospires after heterologous challenge with 101 leptospires of the virulent L. interrogans serovar Copenhageni strain Spool. The Wilcoxon log rank test was used to determine significant survival differences between the immunized groups and the control (empty pTARGET plasmid) group. The groups immunized with killed whole leptospires and LigBrep show P values of <0.05.
