Table 2.
Sterol uptake overview
| Conditiona | Sterol uptake |
||
|---|---|---|---|
| S. cerevisiae | C. albicans | C. glabrata | |
| Aerobic exclusion | ± | – | – |
| Anaerobic exclusion | – | + | – |
| Tween 80 supports microaerophilic growth | ± | – | ± |
| Tween 80 and sterols support microaerophilic growth | + | – | + |
| Sterol supplement overcomes FLC inhibition microaerophilically | + | – | + |
| FBS stimulates sterol uptake | – | – | – |
| FLC stimulates sterol uptake | + | – | – |
| FBS plus FLC stimulates sterol uptake | + | – | + |
| Anaerobic growth of UPC2 mutant | – | – | – |
| Upc2 involved in serum-stimulated sterol uptake in the presence of FLC | – | – | + |
| Upc2 involved in normoxic post-exponential-phase sterol uptake | – | – | – |
| Aus1/Pdr11 required for aerobic sterol uptake* | + | NHb | – |
| Aus1/Pdr11 required for microaerophilic sterol uptake* | + | NH | + |
a
FBS, fetal bovine serum; FLC, fluconazole. *, In S. cerevisiae both ScAus1 and ScPdr11 paralogs are required, while in C. glabrata, only one ortholog, CgAus1, is present.
b
NH, no homolog.