Table 2.
Comparison of GM ELISA, Aspergillus real-time PCR, and Aspergillus LFD sample positivity in the different patient populationsa
| Patient population |
% assay sample positivitya (% difference; 95% CI; P) |
||
|---|---|---|---|
| GM vs PCR | GM vs LFD | PCR vs LFD | |
| Proven IA | 14.9 vs 28.2 (13.3; 0.43–26.1; 0.0501) | 14.9 vs 17.2 (2.3; −8.8–13.3; 0.8389) | 28.2 vs 17.2 (11.0; 24.0–−2.1; 0.1240) |
| Proven/probable IA | 31.0 vs 27.9 (3.1; 12.1–−6.0; 0.5050) | 31.0 vs 26.6 (4.4; 13.1–−4.4; 0.3807) | 27.9 vs 26.6 (1.3; 10.2–−7.6; 0.8192) |
| Proven/probable/possible IA | 17.8 vs 29.1 (11.3; 4.9–17.5; 0.0007) | 17.8 vs 20.1 (2.3; −3.5–8.0; 0.5019) | 29.1 vs 20.1 (9.0; 2.5–15.4; 0.0072) |
| No IFD | 9.7 vs 10.8 (1.1; −5.3–8.1; 0.7236) | 9.7 vs 5.7 (4.0; 9.9–−1.7; 0.2289) | 10.8 vs 5.7 (5.1; 11.6–−5.1; 0.1128) |
a
Please note that positivity in cases (proven/probable/possible IA) represents “true positivity” and positivity in controls (No IFD) represents “false positivity.” Significant differences are represented in bold text.