Table 2.
Drugb | Peak serum drug concn (mg/liter) | Microorganism/bottle type | Serum drug concn (mg/liter) causing ≥3-h delay | 95% CI (mg/liter) |
---|---|---|---|---|
AMC | 11.6 | MSSA/FA | 1 | 1–2 |
MSSA/FN | 6 | 3–42 | ||
MRSA/FA | 21 | 12–98 | ||
MRSA/FN | 55 | 46–70 | ||
S. epidermidis/FA | 0.4 | 0.39–0.41 | ||
S. epidermidis/FN | 2 | 1–5 | ||
K. pneumoniae KP2/FA | 15 | 11–21 | ||
K. pneumoniae KP2/FN | 15 | 22–158 | ||
CTX | 214.1 | K. pneumoniae KP1/FA | 204 | 182–233 |
K. pneumoniae KP1/FN | 89 | 61–167 | ||
CIP | 4.6 | MSSA/FA | 191 | 96–380 |
S. pneumoniae SP2/FN | 58 | 35–178 | ||
P. aeruginosa/FA | 39 | 29–61 | ||
P. aeruginosa/FN | 22 | 18–27 | ||
E. coli/FA | 6 | 6–7 | ||
E. coli/FN | 4 | 3–5 | ||
K. pneumoniae KP2/FA | 3 | 3–3 | ||
K. pneumoniae KP2/FN | 2 | 1–5 | ||
FLC | 6.72 | C. albicans/FN | 249 | 151–704 |
GEN | 7.6 | S. epidermidis/FA | 43 | 34–57 |
S. epidermidis/FN | 27 | 21–38 | ||
E. coli/FA | 251 | 126–500 | ||
E. coli/FN | 146 | 73–292 | ||
K. pneumoniae KP2/FN | 265 | 132–532 | ||
LZD | 12.7 | MSSA/FN | 1,292 | 841–2,787 |
MEM | 62 | MSSA/FN | 15 | 8–95 |
MRSA/FA | 6 | 4–30 | ||
MRSA/FN | 123 | 94–179 | ||
S. epidermidis/FN | 6 | 4–15 | ||
P. aeruginosa/FN | 36 | 23–83 | ||
K. pneumoniae KP1/FN | 36 | 21–125 | ||
K. pneumoniae KP2/FN | 38 | 26–71 | ||
MZ | 26 | B. fragilis/FN | 2 | 1–2 |
FEB | 163.9 | P. aeruginosa/FA | 4,141 | 2,619–9,886 |
P. aeruginosa/FN | 28 | 26–31 | ||
TZP | 224 | MSSA/FA | 288 | 231–384 |
MSSA/FN | 222 | 199–251 | ||
MRSA/FA | 634 | 478–945 | ||
MRSA/FN | 590 | 542–647 | ||
S. epidermidis/FA | 448 | 390–526 | ||
S. epidermidis/FN | 428 | 383–485 | ||
P. aeruginosa/FN | 4,692 | 3,465–7,263 | ||
TGC | 1.45 | S. pneumoniae SP2/FA | 14 | 8–114 |
S. pneumoniae SP2/FN | 32 | 17–226 | ||
K. pneumoniae KP2/FA | 32 | 19–115 | ||
K. pneumoniae KP2/FN | 32 | 20–72 | ||
VAN | 25 | E. faecium/FA | 221 | 156–380 |
E. faecium/FN | 120 | 88–190 | ||
S. epidermidis/FA | 961 | 541–1,707 |
Only microorganism-substance combinations for which the TTD was significantly different from control (control data not shown) were used for calculations. Concentrations are rounded to whole numbers.
AMC, amoxicillin-clavulanate; CTX, cefotaxime; CIP, ciprofloxacin; FLC, fluconazole; GEN, gentamicin; LZD, linezolid; MEM, meropenem; MZ, metronidazole; FEB, cefepime; TZP, piperacillin-tazobactam; TGC, tigecycline; VAN, vancomycin.