. 2013 May;51(5):1534–1540. doi: 10.1128/JCM.00103-13

Table 2.

Estimated serum drug concentrations that led to TTD delays of ≥3 h^a

Drug^b	Peak serum drug concn (mg/liter)	Microorganism/bottle type	Serum drug concn (mg/liter) causing ≥3-h delay	95% CI (mg/liter)
AMC	11.6	MSSA/FA	1	1–2
		MSSA/FN	6	3–42
		MRSA/FA	21	12–98
		MRSA/FN	55	46–70
		S. epidermidis/FA	0.4	0.39–0.41
		S. epidermidis/FN	2	1–5
		K. pneumoniae KP2/FA	15	11–21
		K. pneumoniae KP2/FN	15	22–158
CTX	214.1	K. pneumoniae KP1/FA	204	182–233
		K. pneumoniae KP1/FN	89	61–167
CIP	4.6	MSSA/FA	191	96–380
		S. pneumoniae SP2/FN	58	35–178
		P. aeruginosa/FA	39	29–61
		P. aeruginosa/FN	22	18–27
		E. coli/FA	6	6–7
		E. coli/FN	4	3–5
		K. pneumoniae KP2/FA	3	3–3
		K. pneumoniae KP2/FN	2	1–5
FLC	6.72	C. albicans/FN	249	151–704
GEN	7.6	S. epidermidis/FA	43	34–57
		S. epidermidis/FN	27	21–38
		E. coli/FA	251	126–500
		E. coli/FN	146	73–292
		K. pneumoniae KP2/FN	265	132–532
LZD	12.7	MSSA/FN	1,292	841–2,787
MEM	62	MSSA/FN	15	8–95
		MRSA/FA	6	4–30
		MRSA/FN	123	94–179
		S. epidermidis/FN	6	4–15
		P. aeruginosa/FN	36	23–83
		K. pneumoniae KP1/FN	36	21–125
		K. pneumoniae KP2/FN	38	26–71
MZ	26	B. fragilis/FN	2	1–2
FEB	163.9	P. aeruginosa/FA	4,141	2,619–9,886
		P. aeruginosa/FN	28	26–31
TZP	224	MSSA/FA	288	231–384
		MSSA/FN	222	199–251
		MRSA/FA	634	478–945
		MRSA/FN	590	542–647
		S. epidermidis/FA	448	390–526
		S. epidermidis/FN	428	383–485
		P. aeruginosa/FN	4,692	3,465–7,263
TGC	1.45	S. pneumoniae SP2/FA	14	8–114
		S. pneumoniae SP2/FN	32	17–226
		K. pneumoniae KP2/FA	32	19–115
		K. pneumoniae KP2/FN	32	20–72
VAN	25	E. faecium/FA	221	156–380
		E. faecium/FN	120	88–190
		S. epidermidis/FA	961	541–1,707

Only microorganism-substance combinations for which the TTD was significantly different from control (control data not shown) were used for calculations. Concentrations are rounded to whole numbers.

AMC, amoxicillin-clavulanate; CTX, cefotaxime; CIP, ciprofloxacin; FLC, fluconazole; GEN, gentamicin; LZD, linezolid; MEM, meropenem; MZ, metronidazole; FEB, cefepime; TZP, piperacillin-tazobactam; TGC, tigecycline; VAN, vancomycin.