Table 2.

Patterns of results of GenoType MTBDRplus in comparison to DST and sequencing (n = 62)

Agreement	No. of samples	DST resulta		Sequencing result			GenoType MTBDRplus resulta,b
		RMP	INH	RpoB	KatG	InhA	RpoB	KatG	InhA
Total agreement	13c	S	S	WT	WT	WT	WT	WT	WT
	11	R	R	S531L (TCG-TTG)	S315T (AGC-ACC)	WT	Δwt8 + Mut3	Mut1e	WT
	8	S	R	WT	S315T (AGC-ACC)	WT	WT	Mutd	WT
	3	R	R	H526Y (CAC-TAC)	S315N (AGC-AAC)	WT	Δwt7 + Mut2Ae	ΔkatGwt	WT
	1	R	S	S531L (TCG-TTG)	WT	WT	Δwt8 + Mut3	WT	WT
	1	S	R	WT	S315N (AGC-AAC)	−15C-T	WT	ΔkatGwt	Mut1e
	1	R	R	Insertion in codon 516 (CCAGAACAACCC)	S315T (AGC-ACC)	WT	Δwt3	Mut1e	WT
	1	R	R	S531L (TCG-TTG)	WT	−15C-T	Δwt8 + Mut3e	WT	Mut1e
	1	S	R	WT	WT	−15C-T	WT	WT	Mut1e
Some disagreement	1	R*	R	WT	S315N (AGC-AAC)	WT	WT	ΔkatGwt	WT
	2	R	R	Insertion in codon 516 (CCAGAACAACCC)	S315T (AGC-ACC)	WT	WT*	Mut1e	WT
	9	S	R*	WT	WT	WT	WT	WT	WT
	1	S	R*	WT	WT	WT	Δwt8 + Mut3	WT	WT
	1	S*	R*	S531L (TCG-TTG)	WT	WT	Δwt8 + Mut3e	WT	WT
	1	R	R*	H526D (CAC-GAC)	WT	WT	Δwt7 + Mut2Be	WT	WT
	3	R	R*	S531L (TCG-TTG)	WT	WT	Δwt8 + Mut3e	WT	WT
	2	R	R*	D516H (GAC-CAC) + H526D (CAC-GAC)	WT	WT	Δwt3, Δwt4, Δwt7, and Mut2Be	WT	WT
	2	R*	R*	WT	WT	WT	WT	WT	WT

^a*, discordant result.

^bΔ, absence of hybridization signal with the wild-type probes.

^cOne sample was monoresistant to streptomycin.

^dTwo strains showed a wild-type and mutation probe-positive hybridization pattern together.

^ePositive hybridization result with the specified mutant probe.