Table 1.

Putative virulence-associated genes detected in S. epidermidis strain CSUR P278^a

Gene category and function	Gene name	Contig no.-ORF	Function(s)
Biofilm formation
Primary attachment	atlE	34-2	Autolysin
	sdrG (fbe)	10-1	Fibrinogen-binding protein
	sdrF	15-49	Ser-Asp-rich fibrinogen-binding protein, surface adhesin
	sdrH	17-31	Ser-Asp-rich fibrinogen-binding protein, surface adhesin
	sdrG	31-1	Ser-Asp-rich fibrinogen-binding protein, surface adhesin
	ebp	1-48	Elastin-binding protein
	ebh	1-88	Cell wall-associated fibronectin-binding protein
	ebha	1-90	EbhA protein
Intercellular aggregation and protective exopolymers	icaA	3-100	Poly N-acetylglucosamine, protects from IgG, AMPs, phagocytosis, and complement
	icaB	3-98	Poly N-acetylglucosamine, protects from IgG, AMPs, phagocytosis, and complement
	icaC	3-97	Poly N-acetylglucosamine, protects from IgG, AMPs, phagocytosis, and complement
	icaD	3-99	Poly N-acetylglucosamine, protects from IgG, AMPs, phagocytosis and complement
	icaR	3-101	Poly N-acetylglucosamine, protects from IgG, AMPs, phagocytosis, and complement
	capA	4-89	Poly-γ-glutamyl acid, protects from AMPs and phagocytosis
	capB	6-6	Poly-γ-glutamyl acid, protects from AMPs and phagocytosis
	capC	6-7	Poly-γ-glutamyl acid, protects from AMPs and phagocytosis
	capD	6-10	Poly-γ-glutamyl acid, protects from AMPs and phagocytosis
	sepA	26-3	Protease, AMP degradation
Resistance to AMPs	dltA	18-30	Dealanylation of teichoic acids
	dltB	18-31	Dealanylation of teichoic acids
	dltC	18-32	Dealanylation of teichoic acids
	dltD	18-33	Dealanylation of teichoic acids
	mprF	1-172	Lysylation of phospholipids
	vraF	5-71	AMP exporter
	vraG	5-72	AMP exporter
	aprR	5-69	AMP sensor
	aprS	5-70	AMP sensor
Exoenzymes
	sspA	51-4	Serine protease, V8 protease
	sspB	3-4	Serine protease precursor
	geh	15-40, 3-5, 3-6	Glycerol ester hydrolase, lipase
	lip	3-96	Lipase A
Toxins
	psmβ	2-39	Beta-hemolysin
	ficD	7-68	Toxin
Antitoxin		7-67	Antitoxin

^aAMPs, antimicrobial peptides.