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LPA stimulates the expression of Gαq and PLC-β1 in the proliferating crypt compartment of the intestinal tract. Intestinal sections of WT and Lpar1−/− mice treated with LPA were stained with anti-Gαq (A) or anti-PLC-β1 (B) antibody. n = 5. Bars, 50 μm. (C) A model of LPA1-dependent effects on IECs is shown.
