Fig 1.

Dose-dependent survival of infected humanized mice and controls. (A) Survival curves of Streptococcus agalactiae (GBS)-infected humanized mice. (B) Survival curves of 1 × 10⁶ GBS-infected humanized mice and conditioned control mice (irradiated but not reconstituted with human CD34⁺ cells). Numbers of animals are indicated in parentheses. Statistical differences were calculated using Mantel-Cox (log rank) test (***, P < 0.001). (C) CFU count for each organ was determined after 1 day of high-dose infection (left graph, 10⁷ CFU GBS; n = 10) and 3 days (middle graph, n = 10) and 7 days (right graph, n = 6) of moderate-dose (1 × 10⁶) infection.