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The early dissemination defect is dependent on an acquired immune response. Shown are copy numbers of B. burgdorferi flaB DNA per mg tissue (mean ± SEM) in heart base (A) and tibiotarsus (B) from C3H-scid mice and heart base (C) and tibiotarsus (D) from C3H mice at days 14, 28, 42, 60, and 90 postinoculation. Mice were inoculated with B31-ΔdbpBA (white circles) or wild-type B31-A3 (black circles). Each data point represents 4 to 9 mice from 2 separate experiments. *, P ≤ 0.035.
