Fig 1.
MyD88 signaling plays an essential role in host responses against E. coli K1 meningitis. (A) Survival following E. coli K1 infection (5.5 × 103 CFU/mouse) was significantly lower in myd88−/− mice (0%; P = 0.0006; log rank test) than in C57BL/6 wt mice (43%). After 30 h of infection, bacterial counts in cerebellum (B) and spleen (C) homogenates of myd88−/− mice were significantly higher than those found in wt controls (P = 0.0003; Mann-Whitney U test). Symbols in panels B and C represent individual mice, and bars indicate median values.