Fig 3.

Cell-autonomous function of Bmal1 in β cells is required for normal glucose homeostasis. (A and B) Plasma glucose and insulin levels of 8-week-old mice at ZT4 during a GTT. (C and D) Plasma glucose levels during an ITT at ZT8. Panel C displays the absolute glucose levels during the ITT, and panel D shows the percent decrease from the baseline. (E) Acute insulin secretion after glucose stimulation in 10-week-old mice at ZT4. All groups had five mice, except the Rip-Cre control group, which had three. All values are means ± the standard errors of the means. *, P ≤ 0.05 compared to all of the control groups; +, P ≤ 0.05 compared to the wild-type (WT) and Rip-Cre control groups.