Fig 8.

Shift work-simulating CD protocol. (A) The shift work-simulating CD protocol is shown for a 2-week period with alternating light phase advancement and delay. Mice were on a weekly schedule with normal 12-h light-dark cycles (lights on at 6 am and off at 6 pm) for the first 3 days of the week and then subjected to a 6-h light-dark phase advancement for the next 4 days (lights on at 12 midnight and off at 12 noon). This cycle was repeated for the duration of the study. (B) Body weight, which was measured weekly for the duration of the experiment. Control, normal 12-h light-dark cycles. n = 4 or 5. All values are means ± the standard errors of the means.