Fig 2.

Overall structural organization of autoinhibited ZAP-70 and Syk. Domain organizations and crystal structures are shown for ZAP-70 (this work) (A) and Syk (PDB code 4FL2) (B). The two crystal structures are superimposed around the C lobes of the kinase domains. Disordered regions are depicted as dotted lines. The side chains of Tyr 315 and Tyr 319 in ZAP-70 and Tyr 348 and Tyr 352 in Syk are shown as spheres. A simulated-annealing composite omit map (A, right panel) (residues 305 to 323, contoured at 1.2 σ) is shown for the SH2-kinase linker of ZAP-70 (gray mesh representation).