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Effects of insertions and deletions in the SAM-binding/active-site motif on the N7-MTase activity
| nsp14 | Position |
abd1Δ complementationa at: |
Methylation in vitro (%) | |||
|---|---|---|---|---|---|---|
| 20°C | 25°C | 30°C | 37°C | |||
| Wild type | +++ | +++ | +++ | +++ | 100 | |
| AxGxGxG | 331–337 | − | − | − | − | 0 |
| DIG→DAIG(332) | 332 | − | − | − | − | 3 |
| ΔI332 | 332 | − | − | − | − | 0 |
| DIG→DIAG(333) | 333 | − | − | − | − | 0 |
| ΔN334 | 334 | − | − | − | − | 0 |
| ΔP335 | 335 | − | − | − | − | 0 |
| ΔK336 | 336 | − | − | − | − | 0 |
| ΔA337 | 337 | − | − | − | − | 0 |
