Fig 1.
Schematic representation of wild-type E3/19K (EEE), murine MHC-I Kd (KKK), and various chimeric proteins. The composition of the chimera is indicated on the left by three capital letters representing the ER luminal, transmembrane, and cytoplasmic domains, respectively. An “E” refers to E3/19K-derived sequences (open rectangles) and a “K” to Kd-specific sequences (shaded rectangles). Asterisks denote mutation of the dilysine motif. All constructs were stably transfected into the human embryonic kidney cell line 293.