Fig 2.

Recovery (A) and coreceptor usage (B) of viruses from P3 macaque EL78 and P4 animal GC87. (A) Arrows pointing down indicate the time points of virus recovery; arrows pointing up indicate the times of anti-CD8 antibody administration, at days −5 and −1 and day 14 postinfection. Shaded areas represent the periods when peripheral CD8⁺ T cell depletion was observed, and the dagger indicates the time of EL78 euthanasia. (B) The coreceptor usage of recovered viruses in rhesus PBMCs was determined by blocking with antagonists against CCR5 (TAK779) and CXCR4 (AMD3100). Results are representative of one of two independent experiments.