Fig 4.

GRFT treatment prevents viral dissemination in mice. Medroxyprogesterone-treated mice received a single dose of GRFT or Carbopol gel and 15 min later were intravaginally infected with HSV-2-MS-luciferase (10⁶ PFU in 30 μl). Mice were imaged on days 1 and 4 postinfection, 15 min after receiving an intraperitoneal dose of d-luciferin. Total flux from identical ROIs were compared to total flux from ROI on the control mouse pretreated with medroxyprogesterone, not infected with HSV-2, 15 min after intraperitoneal injection of d-luciferin.