Fig 5.

HSV induces proinflammatory and interferon responses in the genital tract independent of griffithsin treatment. (A) Concentrations of cytokines and chemokines were measured in vaginal washes on days 1 and 2 postinfection. Results are presented as pg/ml in vaginal washes and are means + SEM from 2 to 4 pools of washes from 2 to 5 mice per pool. Asterisks represent significance compared to untreated, uninfected mice using unpaired t test. (B) Gene expression was measured by qRT-PCR on genital tract tissue harvested from 2 to 10 mice on days 1 and 3 postinfection; results are normalized to β-actin and expressed as means + SEM log change relative to control untreated, uninfected mice (*, P < 0.05).