Table 2.
Summary of mutant segments and introduced nucleotide changes
| Gene | Segment | JFH-1 genome location | Size (nt) | No. of nt with: |
Total no. of changes (%) | ||
|---|---|---|---|---|---|---|---|
| No change | Conserved change (%) | Nonconserved change (%) | |||||
| NS3 | S1 | 3872–4156 | 285 | 170 | 85 (29.9) | 30 (10.5) | 115 (40.4) |
| NS3 | S2 | 4157–4441 | 285 | 178 | 88 (30.9) | 19 (6.6) | 107 (37.5) |
| NS3 | S3 | 4442–4726 | 305 | 200 | 85 (27.9) | 20 (6.5) | 105 (34.4) |
| NS3 | S4 | 4727–5011 | 285 | 171 | 86 (30.2) | 28 (9.8) | 114 (40.0) |
| NS3 | S5 | 5012–5299 | 288 | 186 | 87 (30.2) | 15 (5.2) | 102 (35.4) |
| NS4A/B | S6 | 5300–5650 | 351 | 225 | 97 (27.7) | 29 (8.2) | 126 (35.9) |
| NS4B | S7 | 5651–6010 | 360 | 218 | 108 (30.0) | 34 (9.4) | 142 (39.4) |
| NS4B/5A | S8 | 6011–6301 | 291 | 173 | 92 (31.6) | 26 (8.9) | 118 (40.5) |
| NS5A | S9 | 6302–6592 | 291 | 187 | 83 (28.5) | 21 (7.2) | 104 (35.7) |
| NS5A | S10 | 6593–6880 | 288 | 178 | 78 (27.1) | 32 (11.1) | 110 (38.2) |
| NS5A | S11 | 6881–7168 | 288 | 168 | 73 (25.4) | 47 (16.3) | 120 (41.7) |
| NS5A | S12 | 7169–7456 | 288 | 174 | 93 (32.4) | 21 (7.2) | 114 (39.6) |
| NS5A/5B | S13 | 7457–7786 | 330 | 199 | 73 (22.2) | 58 (17.5) | 131 (39.7) |
| 5B | S14 | 7787–8113 | 327 | 193 | 94 (28.8) | 40 (12.2) | 134 (41.0) |
| 5B | S15 | 8114–8440 | 327 | 202 | 91 (27.9) | 34 (10.3) | 125 (38.2) |
| 5B | S16 | 8441–8767 | 327 | 200 | 91 (27.8) | 36 (11.0) | 127 (38.8) |
| 5B | S17 | 8768–9097 | 330 | 201 | 91 (27.6) | 38 (11.5) | 129 (39.1) |
| Total | 6,179 | 3,791 | 1,782 | 606 | 2,388 | ||