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G434 is located on a surface-exposed hexon loop. (A) Ribbon diagram of the DE1 (dark gray), FG1 (black), and FG2 (light gray) loops of HAdV-5 hexon (PDB 1VSZ), with G434 indicated in the FG1 loop. The hexon is orientated for direct comparison with the cryoEM structure of 9C12 in complex with hexon (6). (B) Top view of a surface-rendered model of the HAdV-5 hexon trimer, illustrating the surface exposure of G434. Created with PyMOL.
