Table 2.
Pox counts in mice that received ST-246 at 100 or at 30 mg/kg for 1, 2, 3, or 5 days
| Treatment | Dose (mg/kg) | Avg pox no./animal/day ± SDa at day postinfection: |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | ||
| Expt 1 | |||||||||
| Vehicle (5 days) | 0.9 ± 0.3 | 5.9 ± 0.8 | 9.5 ± 0.9 | 10.3 ± 0.5 | NA | NA | NA | NA | |
| ST-246 (5 days) | 100 | 0** | 0** | 0.3 ± 0.5** | 0** | 0.3 ± 0.5 | 0.3 ± 0.5 | 0.2 ± 0.4 | 0.2 ± 0.4 |
| ST-246 (3 days) | 100 | 0** | 0** | 1.2 ± 1.3** | 3.2 ± 3.5** | 3.3 ± 2.5 | 3.0 ± 2.4 | 1.8 ± 1.6 | 1.3 ± 1.5 |
| ST-246 (2 days) | 100 | 0** | 0.5 ± 0.8** | 2.8 ± 2.1** | 5.2 ± 3.3* | 6.3 ± 2.9 | 7.2 ± 1.8 | 5.3 ± 3.1 | 3.0 ± 1.8 |
| ST-246 (1 day) | 100 | 0** | 1.2 ± 1.2* | 7.7 ± 1.8* | 8.5 ± 1.8* | 9.2 ± 3.1 | 10.2 ± 3.1 | 10.2 ± 2.6 | 7.4 ± 3.5 |
| Expt 2 | |||||||||
| Vehicle (5 days) | 2.0 ± 1.9 | 4.2 ± 2.1 | 7.2 ± 2.9 | 6.7 ± 2.9 | NA | NA | NA | NA | |
| ST-246 (5 days) | 30 | 0* | 1.3 ± 1.2* | 2.7 ± 1.9* | 3.8 ± 2.6 | 4.5 ± 2.4 | 4.7 ± 2.3 | 4.8 ± 3.1 | 4.0 ± 2.9 |
| ST-246 (3 days) | 30 | 0* | 0.8 ± 1.2* | 4.3 ± 1.4 | 5.5 ± 1.2 | 7.5 ± 2.1 | 8.3 ± 2.0 | 8.4 ± 2.2 | 7.8 ± 1.7 |
| ST-246 (2 days) | 30 | 0.3 ± 0.5 | 1.5 ± 1.5 | 4.8 ± 1.5 | 6.0 ± 1.5 | 7.7 ± 2.5 | 4.0 ± 0.0 | NA | NA |
| ST-246 (1 day) | 30 | 0.5 ± 0.8 | 2.7 ± 1.5 | 5.5 ± 2.3 | 8.3 ± 2.9 | 8.0 ± 2.2 | 7.0 ± 0.0 | NA | NA |
a
Poxes on mouse tails were counted using images of individual mice and were used to calculate average pox number per survived animal for each day. Asterisks denote significant differences between ST-246 and vehicle groups in mean daily pox count.
*
, P ≤ 0.05;
**
, P ≤ 0.001. NA, not applicable.