Table 6.
Pox counts in nude mice reconstituted with CD4+ or with CD8+ T cells, infected with IHD-J-Luc VACV, and subjected to treatment with ST-246 for 7 days
| Treatment | Avg pox no./animal/day ± SDa at day postinfection: |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 4 | 5 | 6 | 7 | 8 | 9 | 10 | 14 | 17 | |
| PBS/vehicle | 0 | 2.8 ± 1.0 | 5.0 ± 1.6 | 7.3 ± 1.7 | 8.0 ± 0.0 | 9.0 ± 1.4 | NA | NA | NA |
| CD8+ Tc/vehicle | 1.0 ± 1.0 | 3.3 ± 1.5 | 5.3 ± 0.6 | 6.7 ± 1.2 | 7.0 ± 0.0 | 10.0 ± 0.0 | NA | NA | NA |
| CD8+ Tc/ST-246 | 0 | 0** | 0** | 0** | 0** | 0** | 0 | 0 | 0 |
| CD4+ Tc/vehicle | 1.0 ± 0.0 | 1.7 ± 1.2* | 4.0 ± 1.0 | 4.7 ± 1.5 | 7.7 ± 2.1 | NA | NA | NA | NA |
| CD4+ Tc/ST-246 | 0 | 0** | 0** | 0** | 0** | 0** | 0 | 0 | 0 |
a
Asterisks denote significant differences between PBS/vehicle and all other groups in mean daily pox count.
*
, P ≤ 0.05;
**
, P ≤ 0.001. NA, not applicable.