. 2013 May;87(10):5564–5576. doi: 10.1128/JVI.03426-12

Table 7.

Mean AUC values in nude mice reconstituted with low numbers of T cells, infected with IHD-J-Luc VACV, and treated with ST-246 for 7 days

Adoptive transfer/treatment	No. of adoptively transferred cells	Mean AUC (log₁₀ p/s × day) ± 2×SE^a
		Nasal cavity		Lungs		Spleen		Liver
		D6	D12	D6	D12	D6	D12	D6	D12
PBS/vehicle		45.4 ± 0.3		36.9 ± 1.8		35.4 ± 0.6		37.2 ± 0.7
PBS/ST-246		39.0 ± 0.5^**	92.0 ± 2.9	26.6 ± 0.5^**	64.9 ± 1.7	23.9 ± 1.8^**	63.3 ± 3.8	26.1 ± 0.8^**	67.0 ± 2.3
Tc/ST-246	10⁶	39.7 ± 1.3^**	78.7 ± 3.6^**	27.2 ± 0.7^**	55.9 ± 1.2^**	23.9 ± 1.0^**	49.4 ± 2.0^**	26.1 ± 0.5^**	54.7 ± 1.7^**
Tc/ST-246	10⁵	39.5 ± 2.9^*	87.8 ± 5.8	27.0 ± 0.6^**	59.8 ± 2.0^*	24.6 ± 1.1^**	57.4 ± 4.2	26.5 ± 1.4^**	60.5 ± 4.6^*
CD4⁺ Tc/ST-246	10⁶	40.1 ± 1.2^**	85.9 ± 3.2^*	27.4 ± 0.9^**	58.0 ± 1.7^**	23.2 ± 1.4^**	49.9 ± 2.9^**	26.0 ± 0.8^**	55.0 ± 1.5^**
CD4⁺ Tc/ST-246	10⁵	39.7 ± 2.5^*	89.1 ± 7.0	27.9 ± 1.6^**	60.3 ± 5.2	25.3 ± 2.2^**	56.8 ± 7.8	27.1 ± 1.4^**	60.6 ± 6.4
CD8⁺ Tc/ST-246	10⁶	38.4 ± 1.8^**	78.2 ± 5.4^*	27.3 ± 0.5^**	56.4 ± 0.5^**	23.3 ± 0.7^**	48.7 ± 1.0^**	26.0 ± 0.3^**	54.6 ± 1.2^**
CD8⁺ Tc/ST-246	10⁵	40.4 ± 1.2^**	87.3 ± 3.8	26.9 ± 0.6^**	57.5 ± 2.1^*	23.9 ± 0.9^**	52.2 ± 1.4^*	26.0 ± 0.3^**	57.0 ± 0.1^**

The mean AUC values were calculated for fluxes in mice for days 1 to 6 (D6) and days 1 to 12 (D12) for groups where all of the mice survived during this time frame. For D6, the significance is indicated between mean AUC in PBS/vehicle (boldface values) versus the PBS/ST-246 or Tc/ST-246 groups; for D12, significance is indicated between the PBS/ST-246 (boldface values) and Tc/ST-246 groups. PBS/vehicle, 3 mice per group; CD4⁺ Tc 10⁶/ST-246, 5 mice/group, all other groups, 4 mice per group.

, P ≤ 0.05;

^**

, P ≤ 0.001. p/s, photons per second.