Table 1.

Tumor incidence in EBV-infected mice

EBV	Mouse no.	Donor	Peripheral blood humanization at exposure by cell type (%)a			Peak viral load				Tumor incidence at harveste
						Cell-free		Cell-associated
			CD45+	CD19+	CD3+	No. of DNA copies/ml	Day	No. of DNA copies/ml	Day	Day	Spleen	Liver	Kidney	Other
WT	1b	C	61	12	60	NDd	14	ND	14	14c	−	−	−	−
	2	D	54	52	34	68,347	60	79,197	60	60	+	+	+	−
	3	D	49	40	39	38,892	28	30,174	28	124	−	+	+	−
	4	A	44	40	40	81,495	17	857,847	17	31	+	−	−	−
	5	A	48	47	40	768,867	27	3,087,704	17	27	+	+	−	+
	6	A	37	40	46	141,315	66	302,618	17	66	+	+	+	−
	7	B	14	69	5	928,928	36	1,161,146	27	36	+	+	−	+
REV	8	D	50	42	49	39,011	28	41,642	28	57	−	−	−	−
	9	C	41	21	64	138,293	28	352,638	28	47	+	+	+	−
	10	D	53	35	51	56,797	28	120,803	28	124	+	−	−	−
Δ123	11	C	47	32	49	26,780	54	113,798	54	54	+	+	−	−
	12	C	50	23	53	182,496	83	3,688,297	96	106	−	+	−	−
	13	C	34	17	65	ND	77	21,988	42	77	+	+	−	−
	14	D	43	47	39	6,865	83	100,732	55	95	+	+	−	−
	15	D	64	55	30	ND	34	2,288	34	34	−	−	−	−
	16	D	34	37	52	8,083	42	16,766	42	118	−	−	−	−
	17	A	60	18	68	21,759	28	154,749	28	51	−	−	−	−
	18	B	15	60	1	234,490	55	765,365	42	55	−	+	+	−
	19	B	28	64	19	4,494,995	65	13,414,096	65	65	−	+	+	−
	20	A	44	38	42	52,774	42	17,540	42	51	−	+	−	−
	21	A	22	11	63	380,633	65	513,500	65	65	−	−	+	+

^aGating strategy: live → hCD45⁺ → hCD19⁺ or hCD3⁺ (where h is human).

^bNot included in tumor analyses.

^cEBV DNA detected in spleen and liver at harvest.

^dND, not detected.

^ePresence (+) or absence (−) of tumor(s) is indicated.