Table 1.
Amino acid residue at position 18 (or equivalent) of the alphavirus E2 glycoprotein
| Antigenic complex | Virus | Strain | Source(s) | Location(s) | Yr of isolation | E2 position 18 residue | GenBank accession no. |
|---|---|---|---|---|---|---|---|
| Semliki Forest | Ross River virus | 2975 | Grallina cyanoleuca (bird) | Australia (northeast) | 1965 | Y | ACV67004.1 |
| Ross River virus | 2982 | Microeca fascinans (bird) | Australia (northeast) | 1965 | Y | ACV66994.1 | |
| Ross River virus | 3078 | Poephila personata (bird) | Australia (northeast) | 1965 | Y | ACV66996.1 | |
| Ross River virus | 8961 | Macropus agilis (wallaby) | Australia (northeast) | 1965 | H | ACV66998.1 | |
| Ross River virus | 9057 | Macropus agilis (wallaby) | Australia (northeast) | 1968 | H | ACV67000.1 | |
| Ross River virus | DC5692 | Aedes camptorhynchus | Australia (western) | 1995 | H | ADJ78349.1 | |
| Ross River virus | NB5092 | Aedes vigilax | New South Wales, Australia | 1969 | X | NP_740684.1 | |
| Ross River virus | PW11 | Homo sapiens | Australia (Northwest) | 2009 | H | AEC49766.1 | |
| Ross River virus | PW14 | Homo sapiens | Australia (Northwest) | 2009 | H | AEC49788.1 | |
| Ross River virus | PW7 | Homo sapiens | Australia (Southwest) | 2010 | H | AEC49747.1 | |
| Ross River virus | QML1 | Homo sapiens | Australia (northeast) | 2004 | H | GQ433354 | |
| Ross River virus | SN39 | Homo sapiens | Australia (East Coast) | 2009 | H | AEC49809.1 | |
| Ross River virus | SN85 | Homo sapiens | Australia (Eastern) | 2009 | H | AEC49829.1 | |
| Ross River virus | T48 | Aedes vigilax | Australia (Northern) | 1959 | Y | DQ226993 | |
| Chikungunya virus | 06-027 | Homo sapiens (CS fluid) | Unknown (PMID 16700631) | 2005–2006 | H | CAJ90488.1 | |
| Chikungunya virus | 653496 | Homo sapiens | India (Nagpur) | 2003? | H | AAR84279.1 | |
| Chikungunya virus | Angola M2022 | Unknown | Angola | 1962 | H | ADG95956.1 | |
| Chikungunya virus | ArD 93229 | Aedes dalzieli | Senegal | 1993 | H | ADG95948.1 | |
| Chikungunya virus | DakAr B 16878 | Anopheles (Ceilia) funestus | Central Africa (Bououi) | 1984 | H | ADG95881.1 | |
| Chikungunya virus | DRDE-07 | Homo sapiens | India (Kerala) | 2007 | H | ACA81773.1 | |
| Chikungunya virus | Gibbs 63-263 | Homo sapiens | India | 1963 | H | ADG95936.1 | |
| Chikungunya virus | IND-06-MH2 | Unknown (PMID 17554030) | India (Maharashtra) | 2006 | H | ABN04192.1 | |
| Chikungunya virus | LR2006-OPY1 | Homo sapiens | Reunion Island | 2006 | H | ABD95938.1 | |
| Chikungunya virus | PM2951 | Aedes aegypti | Senegal | 1966 | H | ADG95883.1 | |
| Chikungunya virus | Ross low-passage | Homo sapiens | Tanzania | 1953 | H | ADG95932.1 | |
| Chikungunya virus | RSU1 | Homo sapiens | Indonesia | 1985 | H | ADG95906.1 | |
| Chikungunya virus | S27 | Homo sapiens | Tanzania | 1953 | H | AAO33341.1 | |
| Chikungunya virus | SL-CK1 | Homo sapiens | Sri Lanka | 2007 | H | ADG95913.1 | |
| Chikungunya virus | SL10571 | Homo sapiens | Sri Lanka (Japanese patient) | 2006 | H | BAH97933.1 | |
| Chikungunya virus | SL15649 | Homo sapiens | Sri Lanka | 2006 | H | ACZ72971.1 | |
| Chikungunya virus | TH35 | Homo sapiens | Thailand | 1958 | H | ADG95930.1 | |
| O'nyong-nyong virus | Gulu | Homo sapiens and Anopheles | Uganda | 1959 | H | P22056.1 | |
| O'nyong-nyong virus | SG650 | Homo sapiens | Uganda | 1996 | H | AAC97205.1 | |
| Igbo Ora | IBH10964 | Homo sapiens | Nigeria | 1966 | H | AAC97207.1 | |
| Mayaro virus | TRVL 4675 | Homo sapiens | Trinidad and Tobago | 1954 | Y | AAO33335.1 | |
| Mayaro virus | MAYLC | Homo sapiens (laboratory technician) | French Guiana | 1998 | Y | AAY45742.1 | |
| Getah virus | HB0234 | Culex tritaeniorhynchus Giles | China | 2002 | Y | ABV68937.1 | |
| Getah virus | LEIV 16275 Mag | Aedes sp. | Russia | 2000 | Y | ABR23661.1 | |
| Getah virus | LEIV 17741 | Culex sp. | Mongolia | 2000 | Y | ABR23663.1 | |
| Getah virus | Swine | Porcine | South Korea | 2004 | Y | AAU85260.1 | |
| Getah virus | YN0540 | Armigeres subalbatus | China | 2005 | Y | ABV68939.1 | |
| Sagiyama virus | Original | Adult female mosquitoes | Japan | 1956 | Y | AAO33337.1 | |
| Bebaru virus | Original | Culex sp. | Malaysia | 1956 | Y | AEJ36225.1 | |
| Una virus | Original | Psorophora ferox | Brazil | 1959 | Y | AEJ36237.1 | |
| Semliki Forest virus | A7 | Mosquitoes | Uganda | 1942? | Y | CAD90834.1 | |
| Semliki Forest virus | A774 (A7 strain) | Mosquitoes | Uganda | 1942? | Y | CAA55002.1 | |
| Semliki Forest virus | L10 | Aedes abnormalis | Uganda | 1952 | Y | AAM64227.1 | |
| Semliki Forest virus | Vietnam | Culex tritaeniorhynchus | Vietnam | 1971 | Y | ACB12688.1 | |
| Barmah Forest | Barmah Forest virus | BH2193 | Culex annulirostris | Australia | 1974 | W | NP_054024.1 |
| Western equine encephalitis | Western equine encephalitis virus | 71V1658 | Equine brain | USA | 1971 | F | ACT75286.1 |
| Western equine encephalitis virus | 85-452NM | Culex tarsalis | USA | 1985 | F | ACT75290.1 | |
| Western equine encephalitis virus | Imperial | Culex tarsalis | USA | 2005 | F | ACT75278.1 | |
| Western equine encephalitis virus | McMillan | Homo sapiens | Canada | 1941 | F | ACN87273.1 | |
| Western equine encephalitis virus | Montana-64 | Equine brain | USA | 1967 | F | ACT75282.1 | |
| Highlands J virus | 585-01 | Buteo jamaicensis (hawk) | USA | 2001 | H | ACO59902.1 | |
| Highlands J virus | 744-01 | Strix varia (barred owl) | Georgia | 2001 | H | ACZ34298.1 | |
| Highlands J virus | B-230 | Cyanocitta cristata | Florida | 1960 | H | ACT32135.1 | |
| Fort Morgan virus | CM4-146 | Oeciacus vicarius | Colorado | 1973 | R | ACT68009.1 | |
| Sindbis virus | 631310 | Culex sp. | India | 1963 | T | ACU25461.1 | |
| Sindbis virus | 95M116 | Aedes cinereus | Sweden | 1995 | T | ACU25469.1 | |
| Sindbis virus | B322/23/24 | Motacilla alba | India | 1953 | T | ACU25463.1 | |
| Sindbis virus | Girdwood | Culex univittatus | Egypt | ∼1955 | T | AAA86134.1 | |
| Sindbis virus | hrsp | Unknown | Unknown | Unknown | T | NP_740675.1 | |
| Sindbis virus | MRE-16 | Culex tritaeniorhynchus | Malaysia | 1966–1969 | T | AAC59319.1 | |
| Sindbis virus | SA80-294 | Culex univittatus | Saudi Arabia | 1980 | T | ACU25467.1 | |
| Sindbis virus | SAAR86 | Culex sp. | South Africa | 1954 | T | Unknown | |
| Sindbis virus | SW6562 | Culex annulirostris | Australia | 1990 | T | AAM10630.1 | |
| Sindbis virus | XJ-160 | Anopheles sp. | China | 1990 | T | AAC83379.1 | |
| Ockelbo virus | Edsybn 82-5 | Culiseta sp. | Sweden | 1982 | T | AAA96973.1 | |
| Eastern Equine Encephalitis | Eastern equine encephalitis virus | FL93-1637 | Culex erraticus | Florida | 1993 | D | ADB08661.1 |
| Eastern equine encephalitis virus | MA06 | Phoca vitulina (seal) | Massachusetts | 2006 | D | ACY66806.1 | |
| Eastern equine encephalitis virus | ME77132 | Mosquito | Massachusetts | 1977 | D | AAC53758.1 | |
| Eastern equine encephalitis virus | NJ/60 | Culiseta melanura | New Jersey | 1959 | D | ABQ63086.1 | |
| Eastern equine encephalitis virus | Williams | Equine brain | Connecticut | 1990 | D | AAC53760.1 | |
| Venezuelan equine encephalitis | Venezuelan equine encephalitis virus | 243937 | Horse | Venezuela | 1992 | R | AAC71998.2 |
| Venezuelan equine encephalitis virus | Fe-37c | Culex sp. | Florida | 1963 | R | P36330.1 | |
| Venezuelan equine encephalitis virus | MX01-22 | Syrian hamster | Mexico | 2001 | R | AAW30006.1 | |
| Venezuelan equine encephalitis virus | SH3 | Homo sapiens | Venezuela | 1993 | R | AAC71999.2 | |
| Venezuelan equine encephalitis virus | Trinidad donkey | Donkey | Trinidad and Tobago | 1943 | R | AAC19322.1 | |
| Venezuelan equine encephalitis virus | ZPC738 | Hamster | Venezuela | 1997 | R | AAD27803.1 | |
| Middelburg | Middelburg virus | 857 | Dead horse spleen | Zimbabwe | 1993 | Y | ABP73666.1 |
| Ndumu | Ndumu virus | Original isolate | Aedes sp. | South Africa | 1959 | Y | AEJ36231.1 |