Fig 4.

Fold regulation of selected genes related to NF-κB signaling in human respiratory cells following HPAI H7N3 virus infection. Calu-3 cells were infected with MX/7218 virus at an MOI of 2. Total RNA was isolated in triplicate from cells at 24 h p.i. and examined by real-time RT-PCR array analysis. Genes which exhibited a significant (P < 0.05) >3-fold change in expression over/under that in mock-infected cells are shown. Gray bars signify genes whose regulation is specific for the H7 subtype rather than other influenza viruses in this cell type (17).