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. Author manuscript; available in PMC: 2013 May 8.
Published in final edited form as: Nat Rev Neurosci. 2009 Dec 23;11(3):155–159. doi: 10.1038/nrn2786

Figure 2. New therapeutic approaches.

Figure 2

If trans-cellular propagation of protein misfolding occurs, then new strategies could supplement existing approaches to promote cell survival and block intracellular accumulation of misfolded species. As the cellular mechanisms of aggregate release and uptake are delineated, it may be possible to inhibit these events pharmacologically or genetically. Antibody-based therapies might also be expanded to target protein aggregates that are generated inside a cell and released into the extracellular space.