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Model validation by comparing simulation of single and double gene knock-out mutant growth to experimental observations. (A) Single gene knock-out mutants cultivated in minimal media. (B) Single gene knock-out mutants cultivated in rich YPD media. (C) Double gene knock-out mutants cultivated in rich YPD media. TP = true positive, TN = true negative, FP = false positive and FN = false negative.
