Table 1.
Common copy number genomic alterations in NSCLC found in two cohorts: TCGA and EGFR mutant, non-smoking Asians
| Region of Chromosome | Candidate target genes |
|---|---|
| Gain of 1q21.1q-24.2 |
Large fragment |
| Gain of 5p13.2 |
SKP2 |
| Gain of 7p11.2 |
EGFR |
| Gain of 8q24.3 |
PTP4A3 |
| Gain of 8q24.21 |
MYC, PVT1 |
| Gain of 8q24.12 |
MTBP |
| Loss of 8p23.1 |
UNQ9391, RP1|1, SOX7 |
| Gain of 11q13.2-13.3 |
CYCLIN D1, FGF3, FGF4, FGF19 |
| Gain 12q14.2 |
TBK1, RASSF3 |
| Gain 12q14.3 |
HMGA2 |
| Gain of 12q13.3-14.1 |
CDK4 |
| Gain of 12q12.1 |
KRAS |
| Gain of 12q11.21 |
DDX11 |
| Gain 14q13.3 |
PAX9 |
| Gain of 17q12 |
Her2 |
| Gain of 17q25.3 | TK1, BIRC5 |
Common genomic alterations found in both NSCLC samples with EGFR mutations (9 samples) and those from the TCGA data base [56 samples, probably these rarely have an EGFR mutation (Zhou et al. [14])].