Table 1.
Clinical characteristics
|
HI |
PI |
Control subjects |
p value | |
|---|---|---|---|---|
| n = 6 | n = 5 | n = 6 | ||
| Age (year) |
51.0 ± 6.0 |
53.8 ± 6.1 |
49.7 ± 7.4 |
0.590 |
| Male/female (n) |
2/4 |
2/3 |
2/4 |
0.966 |
| Body mass index, kg/(height)2 |
32.7 ± 10.1 |
29.3 ± 5.5 |
26.6 ± 2.0 |
0.333 |
| ACTH deficiency, n (%) |
6 (100) |
5 (100) |
0 (0) |
|
| GH deficiency, n (%) |
5 (83.3) |
5 (100) |
0 (0) |
|
| TSH deficiency, n (%) |
6 (100) |
4 (80) |
0 (0) |
|
| LH/FSH deficiency, n (%) |
6 (100) |
5 (100) |
0 (0) |
|
| ADH deficiency, n (%) | 2 (33.3) | 0 | 0 (0) |
HI, patients with probable hypothalamic impairment, defined as having a history of surgery in the sellar region, cranial radiotherapy, and compression of the optic chiasm; PI, subjects with pituitary insufficiency but without a history of cranial surgery, radiotherapy, or compression of the optic chiasm.