Figure 2.

LFA-1 MAb binds to CD8+ T cells and dendritic cells. PBMC from 10 HIV-1 negative (open circles) and 11 HIV-1 positive subjects (closed circles) were incubated with LFA-1 MAb and fluorochrome labeled antibodies that differentiated immune cell subsets then analyzed using flow cytometry. Results are expressed as the percent of LFA-1 MAb positive cells within each cell subset for each subject tested. The horizontal line indicates the mean percent within each subset. The mean percent of CD8+ LFA-1 MAb positive cells was significantly higher in HIV infected subjects (p = 0.0151, Mann Whitney test). There was no significant difference in the percent of LFA-1 MAb positive cells in the remaining cell subsets.