Fig. 2.

Simulated models of rater behavior and their impact on fusion performance. The first two examples present traditional models of human observation behavior, and, for both models, STAPLE substantially outperforms a majority voting based approach. In contrast, the third example simulates a typical multi-atlas observation model. In this case, STAPLE is outperformed by a majority vote. Additionally, the multi-atlas fusion approaches that utilize the target-atlas intensity relationships (e.g., locally weighted vote and the proposed Non-Local STAPLE) provide substantial improvement.