Table 2.
Identification of reactive antigens in MMD
| Protein name | Gene symbol | CI* P- value | Fold increase in MMD |
|---|---|---|---|
| Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha (CAMK2A) |
CAMK2A |
5.41E-06 |
18.2 |
| B-cell antigen receptor complex-associated protein alpha-chain |
CD79A |
5.41E-06 |
2.5 |
| EGF-like repeats and discoidin I-like domains 3 (EDIL3) |
EDIL3 |
5.41E-06 |
3.5 |
| Ectonucleoside triphosphate diphosphohydrolase 1 |
ENTPD1 |
5.41E-06 |
2.5 |
| Proteinase 3 |
PRTN3 |
5.41E-06 |
2.1 |
| Calcium/calmodulin-dependent protein kinase ID (CAMK1D), transcript variant 1 |
CAMK1D |
5.95E-05 |
5.1 |
| Ephrin-A3 (EFNA3) |
EFNA3 |
5.95E-05 |
2.6 |
| CD7 molecule (CD7) |
CD7 |
3.57E-04 |
2.1 |
| Na+/K + transporting ATPase interacting 4 (NKAIN4) |
NKAIN4 |
3.57E-04 |
85.2 |
| CDC-like kinase 4 (CLK4) |
CLK4 |
5.47E-04 |
3.8 |
| Interferon, alpha-inducible protein 6 (IFI6) |
IFI6 |
5.47E-04 |
2.6 |
| Casein kinase 1, delta (CSNK1D), transcript variant 1 |
CSNK1D |
1.55E-03 |
5.5 |
| Deiodinase, iodothyronine, type III (DIO3) |
DIO3 |
2.74E-03 |
5.2 |
| Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (FCGR3A) |
FCGR3A |
2.74E-03 |
2.2 |
| RNA Polymerase |
RNA POL |
2.74E-03 |
3.7 |
| Uncharacterized protein C20orf96 |
C20orf96 |
5.42E-03 |
4.5 |
| cDNA clone MGC:31944 IMAGE:4878869, complete cds |
CD247 |
5.42E-03 |
3.0 |
| CD3d molecule, delta (CD3-TCR complex) (CD3D), transcript variant 1 |
CD3D |
5.42E-03 |
2.8 |
| Endoglin (Osler-Rendu-Weber syndrome 1) (ENG) |
ENG |
5.42E-03 |
2.4 |
| Solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) |
SLC2A2 |
5.42E-03 |
3.7 |
| Serine/threonine kinase 25 (STE20 homolog, yeast) (STK25) |
STK25 |
5.42E-03 |
2.2 |
| Transmembrane protein 32 (TMEM32) |
TMEM32 |
5.42E-03 |
10.9 |
| Chromosome 19 open reading frame 39 (C19orf39) |
C19orf39 |
5.42E-03 |
4.1 |
| Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta (CAMK2D), transcript variant 3 |
CAMK2D |
5.42E-03 |
3.8 |
| G protein pathway suppressor 1 |
GPS1 |
5.42E-03 |
4.6 |
| Raptor |
KIAA1303 |
5.42E-03 |
3.0 |
| LPS-responsive vesicle trafficking, beach and anchor containing (LRBA) |
LRBA |
5.42E-03 |
3.5 |
| Melanocortin 2 receptor accessory protein (MRAP), transcript variant 1 |
MRAP |
5.42E-03 |
3.2 |
| NIMA (never in mitosis gene a)-related kinase 3 (NEK3), transcript variant 1 |
NEK3 |
5.42E-03 |
4.3 |
| Receptor (chemosensory) transporter protein 2 (RTP2) | RTP2 | 5.42E-03 | 3.4 |
The following is a subset of the most differentially expressed autoAbs increased by 2 fold or more in MMD compared to healthy controls (p ≤ 0.05).
MMD = moyamoya disease.
* CI p-value = Chebyshev’s Inequality p-value.