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. 2013 Apr 20;10:27. doi: 10.1186/1742-4682-10-27

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Copyright © 2013 Wang et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Simulation results of the Notch signaling model. (A) The oscillating expressions of Notch target genes under conditions of a constant extracellular signal. (B) The expression patterns of Notch target genes after the Dll1 gene was knocked out at time point 120 minutes. (C) The changes of concentration of NICD in the cytoplasm and nucleus and the transcriptional activator after Dll1 was knocked out at time point 120 minutes. (D) The expression patterns of the Hes7 gene after the Lfng gene was knocked out at time point 120 minutes. (E) The expression patterns of the Lfng gene after the Hes7 gene was knocked out at time point 120 minutes. (F) The phase relationships of the Notch target genes, Hes7 and NICD. (G) The changes of concentration of NICD after the Lfng gene was knocked out at time point 120 minutes. (H) The changes of concentrations of NICD and the complex of NICD and RBP-j after the Hes7 gene was knocked out at time point 120 minutes.